| I.S. Markov.
Summary
The group of 399 patients (women of childbearing age, gravidas (N=210) with complicated obstetrical anamnesis, children under 14 (N=189) including newborn children and in the age under 1 year (N=73) with organic defects of nervous system was examined by methods of IFA and PCR on presence of specific antibodies of IgG, IgM classes and DNA HSV1/2. Diagnostic levels of IgG class antibodies have been found in 92% of adults and 34,2% of children in the age under 1 year, in 65,6% – aged from 1 to 6 years and in 82,6% – from 6 to 14 years old. Only in 4,1% women and 10,9% of children with the diagnostic level of anti-IgG have been found specific IgM class antibodies, however less than in 50% their revealing coincided with DNA-positive phase of an infectious process. Replicative forms have been established only in 4,6% of women and in 16,3% of children with diagnostic level of anti-IgG class antibodies to HSV1/2. Direct correlation between the specific IgG diagnostic level height and the infectious process activity has not been found. Replicative forms of HSV1/2 were found more often in patients with low (33%–55% cases) and middle (45–40%) diagnostic levels of anti-IgG than with high ones.
The conclusion has been drawn on the non-informativity of the IgG class antibodies determination and insufficient informativity of the IgM class antibodies determination for verifying of episode of chronic HSV-infection reactivation which could be confirmed by discovering DNA pathogenes in various biosubstrats.
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